Definition of LD50 or Lethal Dose 50 Test

Definition of LD50 or Lethal Dose 50 Test Updated and edited on May 20, 2016 by Michelle A. Rivera, About.com Animal Rights Expert The LD50 test is one of the most controversial and inhumane experiments endured by laboratory animals. â€Å"LD† stands for â€Å"lethal dose†; the â€Å"50† means that half the animals, or 50 percent of the animals forced to endure testing the product, will die at that dose. LD50 value for a substance will vary according to the species involved. The substance may be administered any number of ways, including orally, topically, intravenously, or through inhalation. The most commonly used species for these tests are rats, mice, rabbits, and guinea pigs. Substances tested might include household products, drugs or pesticides. These particular animals are popular with animal testing facilities because they are not protected by the Animal Welfare Act which states, in part:   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   AWA 2143 (A)   Ã¢â‚¬Å"†¦for animal care, treatment, and practices in experimental procedures to ensure that animal pain and distress are minimized, including adequate veterinary care with the appropriate use of anesthetic, analgesic, tranquilizing drugs, or euthanasia;†¦Ã¢â‚¬  The LD50 test is controversial because the results have limited, if any, significance when applied to humans. Determining the amount of a substance that will kill a mouse has little value to human beings. Also controversial is the number of animals frequently involved in an LD50 trial, which may be 100 or more animals. Organizations such as the Pharmaceutical Manufacturers’ Association, U.S. Environmental Protection Agency, and the Consumer Product Safety Commission, among others, have all spoken out publicly against the use of too many animals in order to reach that 50 percent number. Approximately 60-200 animals are used even though the above organizations have indicated that these same tests could be successfully concluded by using only six to ten animals. The tests involved testing for â€Å",,,toxicity of gases and powders (the inhalation LD50), irritancy and internal poisoning due to skin exposure (the dermal LD50), and toxicity of substances injected directly into anim al tissue or body cavities (the injectable LD50),† according to the New England Anti-Vivisection Society, whose mission it is to end animal testing and supporting alternatives to testing on live animals. The animals used are almost never given anesthesia and suffer tremendous pain during these tests. Because of public outcry and advances in science, the LD50 test has been largely replaced by alternative test measures. In â€Å"Alternatives to Animal Testing, (Issues in Environmental Science and Technology)† a number of contributors* discuss alternatives that have been adopted by laboratories around the world including the Acute Toxic Class method, the Up and Down and Fixed Dose procedures.   According to the National Institute of Heath, the Consumer Product Safety Commission strongly discourages the use of the LD50 test, while the Environmental Protection Agency discourages its use, and, perhaps the most unnerving, the Food and Drug Administration does not require the LD50 test for cosmetic testing. Merchants have used the public outcry to their advantage. Some have added the words â€Å"cruelty free† or some other indication that the company does not use animal testing on their finished product. But beware of these claims because there is no legal definition for these labels. So the manufacturer may not test on animals, but it’s entirely possible that the manufacturers of the ingredients which comprise the product are tested on animals. International trade has also added to the confusion. While many companies have learned to avoid testing on animals as a public relations measure, the more the United States opens trades with other countries, the higher the chance that animal testing will again be part of the manufacture of a product previously deemed cruelty free. For example, Avon, one of the first companies to speak out against animal testing, has begun selling their products to China. China requires some animal testing be done on certain products before being offered to the public. Avon chooses, of course, to sell to China rather than stand on ceremony and stick to their cruelty-free guns. And while these tests may or may not involve LD-50, the fact is that all the laws and regulations that have been so hard fought and won by animal-rights activists over the years wont mean a thing in a world where global trade is the norm.   If you want to live a cruelty-free life and enjoy following a vegan lifestyle, you have to be part detective and research the products you use every day. *R E Hester  (Editor),  R M Harrison  (Editor),  Paul Illing  (Contributor),  Michael Balls  (Contributor),  Robert Combes  (Contributor),  Derek Knight  (Contributor),  Carl Westmoreland  (Contributor) Edited by Michelle A. Rivera, Animal Rights Expert

What Are Some Good Adjectives For Resume

What Are Some Good Adjectives For Resume The right adjectives are a vital part of a great resume. While its important to be able to express the roles and responsibilities youve held, the adjectives you use to describe these experiences are what brings them to life. Resume experts know that its difficult to write a resume that engages the interest of employers. If you need someone to edit your CV, just apply for help with your resume. On average, employers spend about 11 seconds scanning a resume. That means you want to make sure you capture their interest by choosing the right adjectives. You can take a boring resume and turn it into something that sells your skills and lands you an interview with descriptions that pack a punch. Before decorating you resume with powerful words, you need to complete the template with core information. Use our guide on writing a resume. A word of caution: though you want to use adjectives, you dont want to overdo them. Think powerful yet tasteful. Dont knock them over the head with your dynamic, enthusiastic, incredible, resourceful self. Instead, consider the areas you want to highlight and choose exciting adjectives to bring out your best qualities. Learn how to choose wisely with the following tips: Use Active Adjectives A lot has been written about using action verbs in the resume. What about active adjectives? Using strong adjectives can have just as big an impact as action verbs. Try including words like â€Å"persistent† â€Å"passionate†, â€Å"enterprising†, â€Å"vigorous† and â€Å"determined†. Be Positive Employers love to know that a candidate has a positive outlook on things. Someone who has a positive attitude can help elevate a companys morale, inspire other team members and allow others to indulge their creativity and innovation. Words such as â€Å"exceptional†, â€Å"optimistic†, â€Å"positive†, â€Å"extroverted†, â€Å"personable† and â€Å"sincere† can make a great impact on an employer. Show Them Youre Flexible Things dont always go as planned and an employee that can handle a curve ball or two is a valued asset to any company. Someone who can think on their feet, withstand pressure and turn a misfortune into an opportunity is worth their weight in gold. Adjectives such as â€Å"dynamic†, â€Å"resourceful†, â€Å"adaptable†, â€Å"broad-minded†, â€Å"versatile† and â€Å"foresight† can sell your skills as an expert troubleshooter. Demonstrate Leadership If the position youre applying for calls for leadership skills, make sure you highlight yours with the right adjectives. Try â€Å"leading†, â€Å"diplomatic†, â€Å"facilitating†, â€Å"team-building† and â€Å"guiding† to let them know that you can lead a project to success. Display Your Dedication An employee who shows loyalty to a company is a valuable assent. Make sure you let a potential employer know that youre â€Å"dedicated†, â€Å"loyal†, â€Å"dependable†, and â€Å"reliable† . Standing by the company in trying times can earn you extra points to future employers. Highlight Your Creativity Someone who can think outside the box can bring a lot to any business. In fact, these are some of the most valued qualities at top companies such as Google and Apple. Tell them how â€Å"innovative†, â€Å"creative†, â€Å"unique†, â€Å"original†, â€Å"inventive† and â€Å"imaginative† you are. While the above can help you impress employers with adjectives, you should also bear the following in mind: Use the Job Description The adjectives used in the job description itself can provide you with the guidance you need. You could go through the effort to find appropriate synonyms, but really, the best way to go is to use the words in the job description. Employers will likely be sifting through a lot of resumes, so its no use being subtle. If theyre looking for a self-starter whos innovative and reliable, then give it to them. Use PAR: Project, Action, Result Sometimes people can go overboard on their adjectives in a resume and employers can get lost in a sea of descriptions. Rather than litter your resume with superfluous adjectives, make sure you apply them effectively by using this method. Use adjectives to describe a project you completed or a skill you possess, an action you executed and the result it produced. Though the job market is highly competitive these days, you can make your resume stand out. Make sure you describe you followed basic resume rules and used the right adjectives.

Theme Essay Example | Topics and Well Written Essays - 500 words

Theme - Essay Example The theme applicable to her story is the importance of developing a strong sense of one's own identity and personal strength, despite challenges and difficulties in life. The essay aims to proffer justifications for the theme of developing a strong sense of identity to enable Ying-ying to regain the life she had, not only for her personal benefit, but more so for her daughter, Lena. Ying-ying’s story through the Moon Lady presented her vivid remembrance of the particularly special day when she was merely four years old and her nursemaid prepared her for the Moon Festival. The depiction of her character was so accurate in portraying a strong sense of fiery identity, always curious, on top of things and wanting to get her way. Despite being told to stay put or to observe traditional norms, Ying-ying defied everything as she narrated running after dragonflies, climbing to the rickshaw with her mother (instead of her amah), running through the length of their boat, watching a bird catch fishes, and falling into the water to be lost during the height of the Moon Festival. With all the commotions, the experience of being lost coincided with the metamorphic loss of her personal identity and strength as the fear that enveloped her during the experience transformed her life to silence and as she failed to relay her wish to the Moon Lady: to be found.

Policies and Procedures to Manage the Release of PHI Research Paper

Policies and Procedures to Manage the Release of PHI - Research Paper Example Mobile phone and other related technology, retrieve personal health information for patients. Rapid exchange of vital medical information helps to quality delivery of medical aid to individuals (Kelly, Vottero & Christie-McAuliffe, 2014). On the contrary, there is a risk of unwanted access to privacy of medical information. It is important that health institutions have policies procedure to guide the process of revealing the medical information of individuals. Agency should implement an information management system to assist in managing health records. There would be effective quality control of health information. Proper health information management harmonizes the differences in law governing the release of medical information. Management of health information is one of the ways to regulate the release of medical information for patients (Kelly, Vottero & Christie-McAuliffe, 2014). The release of health information is an important topic because it dictates the quality of medical delivery. The state laws conflict and there are some states that have different rules governing the release of medical information. There is no uniformity in the state laws governing the protection of a patients medical information. There is varying degree of seriousness in handling the release of medical information for patients. Some states require patient permission to publish his or her personal information. On the contrary, some states do not have significant restrictions in releasing medical information to individuals. It is important to have install management systems that will ensure that there is protection of health information of patients. Installation of better management systems provides tracking of patients information. It is an important component in the implementation of a health care policy. The management should manage patients information in the hospital, and teams

Clock Arithmetic :: essays research papers

Clock Arithmetic The topic of time has always been one of interest to me at least on a philosophical basis. Through the works of Einstein, ancient timepieces and calendars such as Stonehenge, and even theories on past and present, time is everywhere. I chose this topic to perhaps explore further the relevance of clocks and timepieces in mathematics and arithmetic. To gain a better understanding of the mathematical features of time would be rewarding knowing that philosophy and mathematics are closely related. Through what I’ve seen in clock arithmetic the concepts could be taught and applied as early as first grade due to the nature of addition and subtraction involved. Clock Arithmetic is also used for technological reasons. Computer games are manufactured using clock arithmetic to base a character’s position due to the resolution of the screen on a certain axis. Example: Suppose you are playing a video game and the character in the game (let's call him Max) is walking from the left side of the screen to the right side. Max gets to the right side of the screen and keeps walking; he disappears and reappears on the left side of the screen again. If the screen is 12 inches wide and we are keeping track of how far Max is from the left side of the screen, then as soon as he is 12 inches from the left side it's as if he was back at the beginning again. If you put it pictorially, against a clock you’d find that Max would start and end up at the same point. Now I’d like to downgrade and put things in an elementary perspective. If it is 3 o'clock and we add 5 hours to the time that will put us at 8 o'clock, so we could write 3 + 5 = 8. But if it is 11 o'clock and we add 5 hours the time will be 4 o'clock, so we should write 11 + 5 = 4. Now everyone knows that 11 + 5 =16, but there is no 16 on the clock (unless you're on military time). Every time we go past 12 on the clock we start counting the hours at 1 again. If we add numbers the way we add hours on the clock, we say that we are doing clock arithmetic. So, in clock arithmetic 8 + 6 = 2, because 6 hours after 8 o'clock is 2 o'clock.

Ap Bio Work

Label the seven repertories illustrated here, and give a different example of each. Enter answer here Evolutionary Adoption Enter answer environment Response to the here Enter answer Order here Regulation Energy Processing Enter & Development Concept 1. 1 Themes connect the concepts of biology 2. What are emergent properties? Give two examples. Properties that are not present at the preceding level. Reproduction 3. Life is organized on many scales. Figure 1. 4 zooms you in from viewing Earth from space all the way to the level of molecules. As you study this figure, choose the correct label for each picture. Exosphere ecosystem ell organism organelle community tissue molecule population 4. Our study of biology will be organized around recurring themes. Make a list here of the themes that are presented, and give an example that illustrates each theme. Watch for these themes throughout your study this entire year. This will help you see the big picture and organize your thinking. (Go t o the Summary of Key Concepts at the end of the chapter for a concise look at the themes. ) Theme 1 Example Organisms Interact with other organisms and the Physical Environment The leaves of a tree, for example, absorb light from the sun, Theme 2:Life requires energy transfer and transformation Theme 3: Theme 4: A fundamental characteristic of living organisms is their use of energy to carry out life's activities. Theme 5: Theme 6: Theme 7: (Find it in 1. 2. ) Concept 1. 2 The Core Theme: Evolution accounts for the unity and diversity of life 5. Life is organized into groups. Study Figure 1. 14. Which level contains the greatest diversity of organisms? The least? 6. Taxonomy is the branch of biology that names and classifies organisms. Because of new molecular information, there have been many changes in placement of certain groups in recent years.Notice that all life is now organized in your text into 3 domains rather than the 5 kingdoms you may have learned earlier. Choose the kin gdoms mentioned in the text in the space above the proper domain names shown here. Mammalian Protests 7. What two main points were articulated in Darning's The Origin of Species? 8. What did Darwin propose as the mechanism of evolution? Summarize this mechanism. Are the two main types of scientific inquiry? Give an example of each. 10. What is the difference between deductive and inductive reasoning? Is either used by scientists? 1 1 .Distinguish between quantitative and qualitative data. Which type would be resented in a data chart and could be graphed? Which type is found in the field sketches made by Jane Goodwill? 12. In science, how do we define hypothesis? 13. A scientific hypothesis has two important qualities. The first is that it is testable. What is the second? 14. Look at Figure 1. 24. Use it to write a hypothesis using the â€Å"If .. . Then .. .† Format. 15. What is a controlled experiment? 16. The text points out a common misconception about the term â€Å"cont rolled experiment†. In the snake mimicry experiment, what factors were held constant? 7. Explain what is meant by a scientific theory by giving the three ways your text prepares a theory from a hypothesis or mere speculation. Chapter 2: The Chemical Context of Life 2. 3. This chapter covers the basics that you may have learned in your chemistry class. The questions that follow should help you focus on the most important points. Matter element trace element neutron atomic number atomic mass energy polar covalent bond anion compound proton isotope electronegative action dynamic equilibrium essential element electron electron shells monopoly covalent bond hydrogen bond Concept 2. Matter consists of chemical elements in pure form and in combinations called compounds 1. What four elements make up 96% of all living matter? Concept 2. 2 An element's properties depend on the structure of its atoms 2. Below is a model of an atom of helium, correctly label the electrons, protons, neutro ns, and atomic nucleus. 3. What is the atomic number of helium? Its atomic mass? 4. Consider this entry in the periodic table for carbon. What is the atomic mass? Atomic number? How many electrons does carbon have? Neutrons? 5. What are isotopes? Use carbon as an example. 6.Explain radioactive isotopes and one medical application that uses them. 7. Which is the only subatomic particle that is directly involved in the chemical sections between atoms? 8. What is potential energy? 9. Explain which has more potential energy in each pair: a. Boy at the top of a slide/boy at the bottom electron in the third energy shell the chemical behavior of an atom? B. electron in the first energy shell/ c. Water/glucose 10. What determines a. How many valence electrons does it have? B. How many protons does it have? Concept 2. 3 The formation and function of molecules depend on chemical bonding between atoms 12.Now, refer back to your definition of a compound and fill in the following chart: Molecule ? (y/n) Compound? (y/n) Molecular Formula Water Carbon dioxide Methane Structural Formula 02 13. What type of bond is seen in 02? Explain what this means. 14. Choose the correct labels for the electron distribution diagram of water. Which element is most electronegative? Molecule? Why is water considered a polar (This is a very important concept. Spend some time with this one! ) 15. Another bond type is the ionic bond. Explain what is happening in the figure below (2. 14): 16. What two elements are involved above? 17.In the preceding example, which is the anion? 18. Indicate where the hydrogen bond occurs in this figure. Hydrogen 19. Here is a list of the types of bonds and interactions discussed in this section. On the chart: hydrogen bonds, van deer Walls interactions, covalent bonds, ionic bonds. Van deer Walls interactions 20. What is the biological importance of weak bonds? 21 . Use morphine and endorphins as examples to explain why molecular shape is crucial in biology. Concep t 2. 4 Chemical reactions make and break chemical bonds 22. Write the chemical shorthand equation for photosynthesis. Label the reactants and the products. 23.For the equation you Just wrote, how many molecules of carbon dioxide are there? How many molecules of glucose? How many elements in glucose? Chapter 3: Water and the Fitness of the Environment polar molecule specific heat solute pH cohesion evaporation hydrophilic acid adhesion solvent hydrophobic base Concept 3. 1 The polarity of water molecules results in hydrogen bonding 1. Why is water considered polar? 2. How many hydrogen bonds can a single water molecule form? Concept 3. 2 Four emergent properties of water contribute to Earth's fitness for life Hydrogen bonding accounts for the unique properties of water. Let's look at several.Cohesion 3. What is demonstrated when you see beads of water on a waxed car hood? Calorie solution military . Which property explains the ability of a water strider to walk on water? Moderation o f Temperature 5. Water has high specific heat. How does water's specific heat compare to alcohol's? 6. Explain how hydrogen bonding contributes to water's high specific heat. 7. Summarize how water's high specific heat contributes to the moderation of temperature. How is this property important to life? 8. What is heat of vaporization? Explain at least three effects of this property on living organisms. Expansion upon Freezing 9. Ice floats!So what? Consider what would happen if ponds and other bodies of water accumulated ice at the bottom. Describe why this property of water is important. 10. Now, explain why ice floats. Why is ICC the critical temperature in this story? Solvent of Life 1 1 . Consider coffee to which you have added sugar. Which is the solvent? The solute? 12. Explain why water is such a fine solvent. 13. You already know that some materials, such as olive oil, will not dissolve in water. In fact, oil will float on top of water. Explain this property in terms of hyd rogen bonding. 14. Now, let's do a little work that will enable you to prepare solutions.Read the section on solute concentrations carefully, and show the calculations here for repairing a I-molar solution of sucrose. Steps to help you do this follow. The first step is done for you. Fill in the rest. Steps to prepare a solution: a. Write the molecular formula. B. Use your periodic table to calculate the mass of each element. Multiply by the number of atoms of the element. (For example, O has a mass of 16. Therefore one mole of O has a mass of 16 x 11 = 176 g/mole. ) masses of each element in the molecule. C. Add the d. Add this mass of the compound to water to bring it to a volume of 1 liter.

The Virtues of Apathy Essay - 3588 Words

The Virtues of Apathy â€Å"I just dont think I can continue to live in a place that embraces and nurtures apathy as if it was virtue.† Morgan Freeman speaks these words in the movie Se7en after declaring that he is going to quit his job as a detective. His character sees crimes of hate, aggression and murder every day, and he also observes the public’s reaction to them. People turn a blind eye; they no longer care. What has happened to society? Why has what used to be considered incredibly shocking dissolved into what is considered an everyday and usual activity? Apathy has become the common response of American society towards what should be considered shocking because these activities have become unshocking and â€Å"everyday†. In†¦show more content†¦Crying and vomiting, love making and dying, and beauty and sickness are paired together and stressed in his novel Blue of Noon. Bataille’s main character is almost a complete opposite to what is considered a normal human being. The character loves what is evil and debaucherous. He even finds the dead more sexually attractive than the living. Bataille uses this estranged character to perform actions that should be everyday; however, the nature of the character performing the actions unfamiliarizes them. A perfect example of this is when the character is sitting down for an evening meal at a pleasant restaurant. Instead of finishing the meal and his conversation with the woman sitting next to him, the character violently stabs the woman in the leg with his fork (Bataille 39). Such an action is completely out of place, yet it happens as though it is ordinary and everyday. Looking back from a modern perspective, Highmore states that â€Å"Surrealism’s attention to everyday life stands the everyday on its head† (Highmore 49), meaning that the Surrealists accomplished their task of upsetting the normal and confusing the ordinary. However, Highmore also notes the second accomplishment of Surrealism when he says, â€Å"There is a danger that Surrealism’s attempt to make the familiar (the everyday) unfamiliar has itself become all too familiar†Show MoreRelatedIs Sloth Not A Common Problem?1025 Words   |  5 PagesDiligence in itself can become sloth, yet it is also the virtue that protects against sloth. Diligence is a careful effort in work and actions, it is our work ethic- honest labor with diligence in labor, and the scheduling of our time. If work is done in this way, it will guard against slothfulness. Historically, â€Å"acedia tempts the monk toward apathy regarding his commitments or toward avoidance, escape, and distraction from them. Apathy and avoidance comprise two telling symptoms of the vice ofRead MoreThe Fall and Rise of the Roman Empire Essay637 Words   |  3 Pagesits collapse through challenges that would be cataclysmic to the governments of world powers today. 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In addressing society’s disheartened apathy towards the benefits of sex past its immediate pleasurable sensations, West invites people integrate their marriages and sex lives through the TOB providing them with the abilities to fully give themselves to another, discern the desires of the heart and grow in virtue through self-discipline. West has many critics. Cloutier and Mattison, theologians, argue that â€Å"[West] makes the